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HIF-1 activation not only regulates the expression of glycolysis-related enzymes, such as hexokinase and lactate dehydrogenase but also enhances the expression of glucose transporters (GLUT), thereby increasing glucose uptake by tumor cells (51)

Holmes et al, 1998

Two periods of 90 days of trimetazidine (60 mg/day) also increased cardiac phosphocreatine/ATP ratio in nine patients (but three patients showed a decrease), which indicated improved mitochondrial energetics [146]

Arachidonic-Acid-Derived eicosanoids: Roles in biology and immunopathology

For the acquired DOX-resistant PC3 prostate cancer cell line, QUE was found to reverse its resistance by inhibiting c-Met and PI3K/AKT signaling pathways (53)